It's unclear to me what it is you want. One possible interpretation is that you know how much 25\% is, and you want to know how much 75\% is. For this situation it is very easy: if $c$ is 25% of some unknown quantity $y$, and you want to know how much 75% of $y$ is, it is $3c$. For instance, if you know that $27$ is 25% of something, then $3(27)=81$ is 75% of that same something.
The Rule of Three will let you figure out how much $q$% is if you know what $p$% is. If you know that $c$ is $p$% of an unknown quantity, and you want to know how much $q$% of that same quantity will be, then you can set it up as a cross-multiplication problem:
$$\begin{array}{ccc}
c & \text{---} & p\\
x & \text{---} & q
\end{array}$$
so that $x=qc/p$. For example, if you know that $23$ is $17$% of some unknown quantity $x$, and you would like to know who much 77% of that same quantity would be, it is $23(77/17) \approx 104.176$.
But after writing all of the above it strikes me that the question may be even more basic: you have a certain quantity $p$ between $0$ and $50$, which you interpret as a percentage, and you want to know what quantity $q$ is just as far from $50$ but "on the other side". Since you want $q-50 = 50-p$, then you want $q=100-p$.